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A quasi steady-state model (QSM) for accurately predicting the detailed diffusion-dominated dissolution process of polydisperse spheroidal (prolate, oblate, and spherical) particle systems with a broad range of distributions of particle size and aspect ratio has been developed. A rigorous, mathematics-based QSM of the dissolution of single spheroidal particles has been incorporated into the well-established framework of polydisperse dissolution models based on the assumption of uniform bulk concentration. Validation against experimental results shows that this model can accurately predict the increase in bulk concentration of polydisperse systems with various particle sizes and shape parameters. A series of representative instances involving the dissolution of polydisperse felodipine particles at various concentration ratios is used to demonstrate the model’s effectiveness, rendering it a valuable tool for understanding and managing complex systems with diverse particle characteristics.more » « less
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A quasi steady-state model (QSM) for accurately predicting the detailed diffusion-dominated dissolution process of polydisperse spheroidal (prolate, oblate, and spherical) particle systems was presented Part I of this study. In the present paper, the dissolution characteristics of typical polydisperse spheroidal particle systems have been extensively investigated. The effects of the distributions of particle size and shape have been studied by examining the detailed dissolution processes, such as the size reduction rates of individual particles, the increase in bulk concentration, and the dissolution time of the polydisperse systems. Some important factors controlling the dissolution process, including initial particle concentration, smallest and largest particle sizes, and the smallest and largest Taylor shape parameters, have been identified.more » « less
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A quasi-steady-state model of the dissolution of a single prolate or oblate spheroidal particle has been developed based on the exact solution of the steady-state diffusion equation for mass transfer in an unconfined media. With appropriate treatment of bulk concentration, the model can predict the detailed dissolution process of a single particle in a container of finite size. The dimensionless governing equations suggest that the dissolution process is determined by three dimensionless control parameters, initial solid particle concentration, particle aspect ratio and the product of specific volume of solid particles and saturation concentration of the dissolved substance. Using this model, the dissolution processes of felodipine particles are analysed in a broad range of space of the three control parameters and some characteristics are identified. The effects of material properties indicated by the product of specific volume and saturation concentration are also analysed. The model and the analysis are applicable to the system of monodisperse spheroidal particles of the same shape.more » « less
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The heat and mass transfer characteristics of a simple shear flow over a surface covered with staggered herringbone structures are numerically investigated using the lattice Boltzmann method. Two flow motions are identified. The first is a spiral flow oscillation above the herringbone structures that advect heat and mass from the top plane to herringbone structures. The second is a flow recirculation in the grooves between the ridges that advect heat and mass from the area around the tips of the structures to their side walls and the bottom surfaces. These two basic flow motions couple together to form a complex transport mechanism. The results show that when advective heat and mass transfer takes effect at relatively large Reynolds and Schmidt numbers, the dependence of the total transfer rate on Schmidt number follows a power law, with the exponent being the same as that in the Dittus–Boelter equation for turbulent heat transfer. As the Reynolds number increases, the dependence of the total transfer rate on the Reynolds number also approaches a power law, and the exponent is close to that in the Dittus–Boelter equation.more » « less
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